prothrombin time (PT) using thromboplastin that is rivaroxaban sensitive (e.g.unlike dabigatran rivaroxaban does not prolong the thrombin clotting time.In the patient with clinically relevant bleeding: The above considerations should also take into account comorbidities and other situational facotrs Bleeding that requires surgical intervention.uncontrolled progression of the above with worsening symptoms.Major muscle group with resulting compartment syndrome.Local soft tissue hematomas or bleeding from minor wounds to non-life threatening regions.Moderate or severe renal impairment (Creatinine Clearance Risk factors for adverse events with rivaroxaban include: Elimination: About 1/3 is renally excreted unchanged t1/2 is 5 – 9 h (11-13h in the elderly).Metabolism: about 2/3 is metabolised by the liver.Distribution: plasma protein binding is high, at around 95%.orally active direct Factor Xa inhibitor. Non-valvular AF and a high risk of stroke or systemic embolism.Treatment of acute VTE and prevention of subsequent VTE (for pulmonary embolism and deep vein thrombosis).Prevention of VTE following elective hip or knee replacement.Dabigatran etexilate, (trade name, Pradaxa).Examples of currently available NOACs are:.an orally active direct Factor Xa inhibitor (a n example of a NOACs or “New Oral Anticoagulants”).Reviewed and revised 10 July 2014 – based on a summary by James Hayes.
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